UTSW Preclinical Pharmacology Core

Overview of Services

 

About Us: 


The Preclinical Pharmacology Core offers a variety of drug development services to investigators at UT Southwestern as well as external academic clients. The Core was established in 2007 by the Biochemistry Department through the auspices of a program project grant in cancer (NCI PO1 CA095471) and has since expanded to support additional grant-funded research activities as well as fee-for-service projects.


The Pharmacology Core has established assays to evaluate in vitro drug toxicity and specificity against a wide-panel of tumor cell lines, in vitro drug stability using hepatocytes, microsomes, and S9 fractions, drug solubility and formulation for in vivo work, plasma protein binding, and inhibition of cytochrome p450 drug metabolizing enzymes. The Core additionally has experience in administration of novel compounds by various routes (IV, IP, PO, SC) to evaluate both in vivo toxicology and drug pharmacokinetics and when requested to help with studies to evaluate drug efficacy in a variety of models. Finally, the Core has established relationships with several pharmacology contract research organizations for evaluation of off-target interactions of more advanced compounds such as hERG binding and genotoxicity. Assistance with study design, implementation and analysis are provided. Core resources can be accessed on a fee-for-service basis or in a collaborative grant-funded situation. Assistance with grant writing is available. New projects require consultation with the Core director prior to initiation.


The lab is affiliated with UT Southwestern’s Department of Biochemistry and works closely with both the Synthetic Chemistry and High Throughput Screening Cores. The lab is also supported by grants from the National Institutes of Health and the Cancer Prevention and Research Institute of Texas as well as institutional funds from the Institute for Innovations in Medical Technology (IIMT).

 


Mission Statement:


The mission of the Pharmacology Core is to assist investigators in refining and improving the drug-like characteristics of novel small molecule compounds and to provide a resource for evaluating the in vitro and in vivo pharmacokinetic behavior of novel and existing small molecule therapeutics.

News:

 

April 1, 2018:  We are excited to announce that we now have a new triple-quadrupole LC-MS/MS system (Sciex  QTRAP® 6500+) for analysis of client samples.  This brings our instrument total to three, including our older 3200 QTRAP® and 4000 QTRAP® systems.  

 

Leadership

 

Noelle S. Williams, Ph.D. Research Professor

 

Location and hours of operation

Hours Location

Monday - Friday 

8:00 am - 5:00 pm      

Room L4.244/245

5323 Harry Hines Boulevard

Dallas, TX 75390-9038

 

Links and Resources

 

 

Metabolomics Core

The UTSW Biochemistry Department recently established a Metabolomics Core under the leadership of Dr. Hamid Baniasadi.  The Metabolomics Core Facility aims to provide high quality analysis of polar metabolites in biological samples using liquid chromatography mass spectrometry. 

Contacts

Name Role Phone Email Location
Noelle Williams
Core Director
 
214-648-5072
 
noelle.williams@utsouthwestern.edu
 
L4.244
 
Jessica A. Kilgore
Research Scientist
 
214-648-0348
 
jessica.kilgore@utsouthwestern.edu
 
L4.244
 
Kavitha Priya Kettimuthu
Senior Research Associate
 
214-648-0348
 
KavithaPriya.Kettimuthu@UTSouthwestern.edu
 
L4.244
 
Xiaoyu Wang
Research Scientist
 
214-648-0348
 
xiaoyu.wang@utsouthwestern.edu
 
L4.244
 
Sophie Geboers
Senior Research Associate
 
214-648-0348
 
sophie.geboers@utouthwestern.edu
 
L4.244
 
Hamid Baniasadi
Instructor, Metabolomics Core Facility
 
214-648-6927
 
hamid.baniasadi@utsouthwestern.edu
 
Y4.310
 

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