UTSW O'Brien Kidney Research Core Center: Animal Model Core

Overview of Services

The study of genetically modified mice has greatly expanded our understanding of kidney development and pathophysiology. The U.T. Southwestern O’Brien Kidney Center Animal Model Core provides cutting-edge technology to investigators wishing to generate mouse models for the study of kidney development and/or function.

The Animal Model Core serves three major purposes:

To provide the necessary reagents and expertise to mouse geneticists who do not normally study the kidney, to facilitate and encourage their move into this field.
To encourage non-mouse geneticists, especially clinical investigators, to venture into the mouse system and to ease this transition.
To provide tools to mouse geneticists who do study the kidney, to assist in their studies.

The Core generates and distributes several kidney-specific Cre recombinase and tetracycline-inducible activator and repressor lines to be crossed to floxed or tet responder lines provided by co-investigators. Core personnel assist in generating additional transgenic mice, knockout/in mice, and cell lines, as required by co-investigators. Core personnel also use and train investigators to use various models of organ injury/repair and ex vivo culture. As mentioned, the ultimate purpose of this core is to facilitate research on kidney development and pathophysiology.

All publication require the acknowledgment of the support provided from U.T. Southwestern Medical Center of Dallas, George M. O'Brien Kidney Research Core Center (P30DK079328)

Additional Links and Resources:

Location:

U.T. Southwestern Medical Center of Dallas

O'Brien Kidney Center

5323 Harry Hines Blvd.

Dallas, TX 75390 - 8856

Contacts

Name	Role	Phone	Email	Location
Thomas Carroll, Ph.D	Animal Model Core Co-Director	214-648-8147	thomas.carroll@utsouthwestern.edu
Orson W. Moe, M.D.	O'Brien Core Center Director		orson.moe@utsouthwestern.edu
Genelyn Vadney	Research Technician		genelyn.vadney@utsouthwestern.edu	NA8.214

Request/Order Animal Models

Name	Description	Price
Axin2-GFP	GFP transgene under control of Axin2 promoter. Green fluorescence in ub tips and medullary stroma. Can be used as a reporter of beta-catenin activity.	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Btbd11-/-	Null allele of Btbd11	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Cagg-LSL-Wnt9b-IRES-GFP	Cre activatable allele of Wnt9b-IRES-GFP	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
CaggCreERT2	Tamoxifen inducible Cre under control of Cagg promoter (ubiquitous in embryo and adult)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Catnb exon3 flox	Cre activatable allele of beta-catenin	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Catnb flox/flox	Cre inducible null allele of beta-catenin	Internal $150.00 each External $200.00 each
cMyc flox/flox	Cre inducible null allele of cMyc	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
cMyc/Nmyc flox/flox	Cre inducible null allele of cMyc and nMyc	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
EF1a-LSL-Crb3GFP	O'Brien Generated Mouse Model Crb3-GFP fusion transgene under control of EF1a promoter. Cells express GFP in apical side of membrane upon Cre mediated excision of triple polyadenylation site. Complete Crb3 cDNA is also expressed. Expression may have gain of function phenotypes.	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Fam132a -/-	Null allele of Fam132a	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Fam19a5 -/-	Null allele of Fam19a5 (aka Tafa5)	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Fat4+/-	Null allele of Fat4	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Foxd1Cre-eGFP	Cre-GFP fusion under control of Foxd1 promoter (renal stromal progenitor cells and extra-renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Foxd1CreERT2	Tamoxifen inducible Cre under control of Foxd1 promoter (renal stroma and extra-renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Gli1CreERT2	Tamoxifen inducible Cre under control of Gli1 promoter (subset of embryonic and adult renal stroma and extra renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Gucy1a3-GFP	O'Brien Generated Mouse Model GFP transgene under control of Gucy1a3 promoter. Green fluorescence in medullary stroma and extra renal cell types	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Hoxb7Cre	Cre under control of Hoxb7 promoter (Wolffian duct and ureteric bud/collecting ducts and extra-renal cell types including posterior neural crest)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
KspCad-rtTA	O'Brien Generated Mouse Model Ksp-cadherin promoter driving Tet-activator (Tet-off) cDNA (kidney epithelia driver)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
KspCad-tTA	O'Brien Generated Mouse Model Ksp-cadherin promoter driving Tet-activator (Tet-off) cDNA (kidney epithelia driver)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
KspCadherin Cre	O'Brien Generated Mouse Model Cre under control of cadh-17 promoter (embryonic and adult kidney epithelia. Highest activity in distal segments)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
KspCreERT2	O'Brien Generated Mouse Model Tamoxifen inducible Cre under control of cadh-17 promoter (embryonic and adult kidney epithelia. Highest activity in distal segments)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Lats 1 c/c		Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Lats 2 c/c		Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Lats1/2 flox/flox	Cre inducible null allele of Lats 1 and 2	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Lkb1 flox/flox	Cre inducible null allele of Lkb1 (Stk11)	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Mef2c-GFP	O'Brien Generated Mouse Model GFP transgene under control of Mef2c promoter. Green fluorescence in medullary stroma and extra renal cell types	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Meis1-GFP	O'Brien Generated Mouse Model GFP transgene under control of Meis1 promoter. Green fluorescence in all renal stroma and extra renal cell types	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
MTA (Material Transfer Agreement) ONLY	- Requester is only submitting a request for a Material Transfer Agreement. - DO NOT initiate this request if you are also requesting a mouse line from the O'Brien Kidney Center	Inquire
Mycn flox/flox	Cre inducible null allele of NMyc	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Osr1CreERT2	Tamoxifen inducible Cre under control of Osr1 promoter (intermediate mesoderm and extra-renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Pax8-YFP	GFP transgene under control of Pax8 promoter. Yellow fluorescence in renal vesicles, Mullerian duct and extra renal cell types	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Pdgfrb-rtTA	Pdgfrb promoter driving reverse Tet-activator (Tet-On) cDNA (fibroblast/mural cell driver)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Pkd1 flox/flox	Cre inducible null allele of PKD1	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Pkhd1Cre	O'Brien Generated Mouse Model Cre under control of Pkhd1 promoter (late embryonic/postnatal collecting ducts)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Podocin-rtTA	O'Brien Generated Mouse Model Podocin promoter driving reverse Tet-activator (Tet-On) cDNA (podocyte driver)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rarb2Cre	Cre under control of Rarb2 promoter (intermediate mesoderm and extra-renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Reagents	Provided by Patel Lab	Inquire
Rosa LSL Yap5SA	Cre activatable allele of Yap (5 serines mutated to alanine)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-Confetti	YFP, CFP and tomato transgenes under control of Rosa26 promoter. Cells stochastically express one of three fluorophores upon Cre mediated excision of triple polyadenylation site.	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL- Lacz	Beta-galactosidase transgene under control of Rosa26 promoter upon Cre mediated excision of triple polyadenylation site.	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Rosa-LSL- myrTom/myrGFP	Myristoylated (membrane) tomato and Myristoylated (membrane) GFP transgenes under control of Rosa26 promoter. All membranes are red until Cre mediated excision of triple Poly A which allows expression of membrane GFP.	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL- Tomato	Tomato transgene under control of Rosa26 promoter. Cells fluoresce red upon Cre mediated excision of triple polyadenylation site.	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL- YFP	YFP transgene under control of Rosa26 promoter. Cells fluoresce yellow upon Cre mediated excision of triple polyadenylation site.	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL-DTA	Cre activatable allele of Diptheria Toxin A subunit	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL-DTR	Cre activatable allele of Diptheria Toxin receptor	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL-Golgi-cherry	Golgi apparatus localized fluorescent Cherry is activated upon excision of a lox flanked triple poly-A site (lox-stop-lox) by Cre recombinase. Golgi of Cre-expressing cells and their derivatives will be labelled.	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Rosa-LSL-myrTom	O'Brien Generated Mouse Model Myristoylated (membrane) Tomato transgenes under control of Rosa26 promoter. Membranes are non-fluorescent until Cre mediated excision of triple Poly A which allows expression of membrane tomato.	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Rosa-lsl-rtTA	Cre activatable allele of reverse Tet activator (Tet-On)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL-Wnt1GFP	Cre activatable allele of Wnt1-GFP fusion	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa26-tetO-Cre		Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Six2Cre-eGFP	Cre-GFP fusion under control of Six2 promoter (nephron progenitor cells and extra-renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Six2CreERT2	Tamoxifen inducible Cre under control of Six2 promoter (nephron progenitors and extra-renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Slc34a1CreERT2	Tamoxifen inducible Cre under control of Slc34a1 promoter (S1 and S2 segment of proximal tubule)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Smoc2-/-	Null allele of Smoc2	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Smoc2-tdTomato	O'Brien Generated Mouse Model tdTomato transgene under control of Smoc2 promoter. Red fluorescence in outer medullary stroma (embryo and adult) and extra renal cell types	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Smoc2CreERT2	Tamoxifen inducible Cre under control of Smoc2 promoter (outer medullary stroma and broad extra-renal stromal activity)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Sox2Cre	Cre under control of Sox2 promoter (epiblast. Has germline activity in female. Can be used for making null embryos)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Srf flox/flox	Cre inducible null allele of Srf	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
T-CreERT2	Tamoxifen inducible Cre under control of Brachyury promoter (mesoderm)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Taz flox/flox;Yap flox/flox	Cre inducible null allele of Taz and Yap	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Transgenic Core - HNF1NB KO	http://www.utsouthwestern.net/intranet/research/transgenic/	Internal $2,700.00 each External $2,700.00 each
Tre-H2B-GFP	Tet-responsive Histone 2 B-GFP fusion (nuclear GFP)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Tre-H2bGFP	cDNA encoding Histone 2b GFP fusion protein under control of tet-responsive element. Nuclear GFP can be activated (or inactivated) when combined with tet-repressor or activator lines and doxycycline administration.	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Tre-Lin28a	Tet-responsive Lin28a cDNA	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Tre-MycN	Tet-responsive NMyc cDNA	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Wnt4+/-	Null allele of Wnt4	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt7b exon 1 flox	Cre inducible partial loss of function allele of Wnt7b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt7b exon 3 deletion	Null allele of Wnt7b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt7b exon 3-4 deletion	Null allele of Wnt7b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt7b exon3 flox	Cre inducible null allele of Wnt7b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt9b exon 2 flox	Cre inducible null allele of Wnt9b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt9b neo/+	Partial loss of function allele of Wnt9b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt9b+/-	Null allele of Wnt9b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each

Search available services: View: by category alphabetically

Name	Description	Price
▼ ► Cre activatable cDNAs (7)
Cagg-LSL-Wnt9b-IRES-GFP	Cre activatable allele of Wnt9b-IRES-GFP	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Catnb exon3 flox	Cre activatable allele of beta-catenin	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa LSL Yap5SA	Cre activatable allele of Yap (5 serines mutated to alanine)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL-DTA	Cre activatable allele of Diptheria Toxin A subunit	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL-DTR	Cre activatable allele of Diptheria Toxin receptor	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-lsl-rtTA	Cre activatable allele of reverse Tet activator (Tet-On)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL-Wnt1GFP	Cre activatable allele of Wnt1-GFP fusion	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
▼ ► Cre inducible reporters (9)
Name	Description	Price
EF1a-LSL-Crb3GFP	O'Brien Generated Mouse Model Crb3-GFP fusion transgene under control of EF1a promoter. Cells express GFP in apical side of membrane upon Cre mediated excision of triple polyadenylation site. Complete Crb3 cDNA is also expressed. Expression may have gain of function phenotypes.	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-Confetti	YFP, CFP and tomato transgenes under control of Rosa26 promoter. Cells stochastically express one of three fluorophores upon Cre mediated excision of triple polyadenylation site.	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL- Lacz	Beta-galactosidase transgene under control of Rosa26 promoter upon Cre mediated excision of triple polyadenylation site.	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Rosa-LSL- myrTom/myrGFP	Myristoylated (membrane) tomato and Myristoylated (membrane) GFP transgenes under control of Rosa26 promoter. All membranes are red until Cre mediated excision of triple Poly A which allows expression of membrane GFP.	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL- Tomato	Tomato transgene under control of Rosa26 promoter. Cells fluoresce red upon Cre mediated excision of triple polyadenylation site.	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL- YFP	YFP transgene under control of Rosa26 promoter. Cells fluoresce yellow upon Cre mediated excision of triple polyadenylation site.	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rosa-LSL-Golgi-cherry	Golgi apparatus localized fluorescent Cherry is activated upon excision of a lox flanked triple poly-A site (lox-stop-lox) by Cre recombinase. Golgi of Cre-expressing cells and their derivatives will be labelled.	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Rosa-LSL-myrTom	O'Brien Generated Mouse Model Myristoylated (membrane) Tomato transgenes under control of Rosa26 promoter. Membranes are non-fluorescent until Cre mediated excision of triple Poly A which allows expression of membrane tomato.	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Rosa26-tetO-Cre		Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
▼ ► Cre lines (16)
Name	Description	Price
CaggCreERT2	Tamoxifen inducible Cre under control of Cagg promoter (ubiquitous in embryo and adult)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Foxd1Cre-eGFP	Cre-GFP fusion under control of Foxd1 promoter (renal stromal progenitor cells and extra-renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Foxd1CreERT2	Tamoxifen inducible Cre under control of Foxd1 promoter (renal stroma and extra-renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Gli1CreERT2	Tamoxifen inducible Cre under control of Gli1 promoter (subset of embryonic and adult renal stroma and extra renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Hoxb7Cre	Cre under control of Hoxb7 promoter (Wolffian duct and ureteric bud/collecting ducts and extra-renal cell types including posterior neural crest)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
KspCadherin Cre	O'Brien Generated Mouse Model Cre under control of cadh-17 promoter (embryonic and adult kidney epithelia. Highest activity in distal segments)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
KspCreERT2	O'Brien Generated Mouse Model Tamoxifen inducible Cre under control of cadh-17 promoter (embryonic and adult kidney epithelia. Highest activity in distal segments)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Osr1CreERT2	Tamoxifen inducible Cre under control of Osr1 promoter (intermediate mesoderm and extra-renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Pkhd1Cre	O'Brien Generated Mouse Model Cre under control of Pkhd1 promoter (late embryonic/postnatal collecting ducts)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Rarb2Cre	Cre under control of Rarb2 promoter (intermediate mesoderm and extra-renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Six2Cre-eGFP	Cre-GFP fusion under control of Six2 promoter (nephron progenitor cells and extra-renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Six2CreERT2	Tamoxifen inducible Cre under control of Six2 promoter (nephron progenitors and extra-renal cell types)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Slc34a1CreERT2	Tamoxifen inducible Cre under control of Slc34a1 promoter (S1 and S2 segment of proximal tubule)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Smoc2CreERT2	Tamoxifen inducible Cre under control of Smoc2 promoter (outer medullary stroma and broad extra-renal stromal activity)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Sox2Cre	Cre under control of Sox2 promoter (epiblast. Has germline activity in female. Can be used for making null embryos)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
T-CreERT2	Tamoxifen inducible Cre under control of Brachyury promoter (mesoderm)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
▼ ► Dox inducible lines (4)
Name	Description	Price
KspCad-rtTA	O'Brien Generated Mouse Model Ksp-cadherin promoter driving Tet-activator (Tet-off) cDNA (kidney epithelia driver)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
KspCad-tTA	O'Brien Generated Mouse Model Ksp-cadherin promoter driving Tet-activator (Tet-off) cDNA (kidney epithelia driver)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Pdgfrb-rtTA	Pdgfrb promoter driving reverse Tet-activator (Tet-On) cDNA (fibroblast/mural cell driver)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Podocin-rtTA	O'Brien Generated Mouse Model Podocin promoter driving reverse Tet-activator (Tet-On) cDNA (podocyte driver)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
▼ ► Doxycycline inducible reporters (1)
Name	Description	Price
Tre-H2bGFP	cDNA encoding Histone 2b GFP fusion protein under control of tet-responsive element. Nuclear GFP can be activated (or inactivated) when combined with tet-repressor or activator lines and doxycycline administration.	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
▼ ► Reporter Lines Constitutive reporters (6)
Name	Description	Price
Axin2-GFP	GFP transgene under control of Axin2 promoter. Green fluorescence in ub tips and medullary stroma. Can be used as a reporter of beta-catenin activity.	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Gucy1a3-GFP	O'Brien Generated Mouse Model GFP transgene under control of Gucy1a3 promoter. Green fluorescence in medullary stroma and extra renal cell types	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Mef2c-GFP	O'Brien Generated Mouse Model GFP transgene under control of Mef2c promoter. Green fluorescence in medullary stroma and extra renal cell types	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Meis1-GFP	O'Brien Generated Mouse Model GFP transgene under control of Meis1 promoter. Green fluorescence in all renal stroma and extra renal cell types	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Pax8-YFP	GFP transgene under control of Pax8 promoter. Yellow fluorescence in renal vesicles, Mullerian duct and extra renal cell types	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Smoc2-tdTomato	O'Brien Generated Mouse Model tdTomato transgene under control of Smoc2 promoter. Red fluorescence in outer medullary stroma (embryo and adult) and extra renal cell types	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
▼ ► rtTA/tTA inducible cDNAS (3)
Name	Description	Price
Tre-H2B-GFP	Tet-responsive Histone 2 B-GFP fusion (nuclear GFP)	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Tre-Lin28a	Tet-responsive Lin28a cDNA	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
Tre-MycN	Tet-responsive NMyc cDNA	Internal $100.00 each External $150.00 each Commercial/Industry $400.00 each
▼ ► Loss of Function Alleles: Germline Nulls (10)
Name	Description	Price
Btbd11-/-	Null allele of Btbd11	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Fam132a -/-	Null allele of Fam132a	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Fam19a5 -/-	Null allele of Fam19a5 (aka Tafa5)	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Fat4+/-	Null allele of Fat4	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Smoc2-/-	Null allele of Smoc2	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt4+/-	Null allele of Wnt4	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt7b exon 3 deletion	Null allele of Wnt7b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt7b exon 3-4 deletion	Null allele of Wnt7b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt9b neo/+	Partial loss of function allele of Wnt9b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt9b+/-	Null allele of Wnt9b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
▼ ► Reagents (1)
Name	Description	Price
Reagents	Provided by Patel Lab	Inquire
▼ ► Transgenic Core - HNF1NB KO (1)
Name	Description	Price
Transgenic Core - HNF1NB KO	http://www.utsouthwestern.net/intranet/research/transgenic/	Internal $2,700.00 each External $2,700.00 each
▼ ► MTA ONLY (1)
Name	Description	Price
MTA (Material Transfer Agreement) ONLY	- Requester is only submitting a request for a Material Transfer Agreement. - DO NOT initiate this request if you are also requesting a mouse line from the O'Brien Kidney Center	Inquire
▼ ► Conditional Alleles (14)
Name	Description	Price
Catnb flox/flox	Cre inducible null allele of beta-catenin	Internal $150.00 each External $200.00 each
cMyc flox/flox	Cre inducible null allele of cMyc	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
cMyc/Nmyc flox/flox	Cre inducible null allele of cMyc and nMyc	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Lats 1 c/c		Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Lats 2 c/c		Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Lats1/2 flox/flox	Cre inducible null allele of Lats 1 and 2	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Lkb1 flox/flox	Cre inducible null allele of Lkb1 (Stk11)	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Mycn flox/flox	Cre inducible null allele of NMyc	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Pkd1 flox/flox	Cre inducible null allele of PKD1	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Srf flox/flox	Cre inducible null allele of Srf	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Taz flox/flox;Yap flox/flox	Cre inducible null allele of Taz and Yap	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt7b exon 1 flox	Cre inducible partial loss of function allele of Wnt7b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt7b exon3 flox	Cre inducible null allele of Wnt7b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each
Wnt9b exon 2 flox	Cre inducible null allele of Wnt9b	Internal $150.00 each External $200.00 each Commercial/Industry $400.00 each

UTSW O'Brien Kidney Research Core Center: Animal Model Core

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