zArchived - UTSW O'Brien Kidney Research Core Center: Animal Model Core


Overview of Services

The study of genetically modified mice has greatly expanded our understanding of kidney development and pathophysiology. The U.T. Southwestern O’Brien Kidney Center Animal Model Core provides cutting-edge technology to investigators wishing to generate mouse models for the study of kidney development and/or function.

The Animal Model Core serves three major purposes:

  • To provide the necessary reagents and expertise to mouse geneticists who do not normally study the kidney, to facilitate and encourage their move into this field.
  • To encourage non-mouse geneticists, especially clinical investigators, to venture into the mouse system and to ease this transition.
  • To provide tools to mouse geneticists who do study the kidney, to assist in their studies.

The Core generates and distributes several kidney-specific Cre recombinase and tetracycline-inducible activator and repressor lines to be crossed to floxed or tet responder lines provided by co-investigators. Core personnel assist in generating additional transgenic mice, knockout/in mice, and cell lines, as required by co-investigators. Core personnel also use and train investigators to use various models of organ injury/repair and ex vivo culture. As mentioned, the ultimate purpose of this core is to facilitate research on kidney development and pathophysiology.

All publication require the acknowledgment of the support provided from U.T. Southwestern Medical Center of Dallas, George M. O'Brien Kidney Research Core Center (P30DK079328)


 Additional Links and Resources:

  1. O'Brien Kidney Center Overview
  2. O'Brien Kidney Center Core Services
  3. O'Brien Kidney Center Animal Model Core
  4. O'Brien Kidney Center Physiology Core
  5. O'Brien Kidney Center Cell Biology, Pathology and Imaging Core
  6. O'Brien Kidney Center Clinical and Translational Core



U.T. Southwestern Medical Center of Dallas

O'Brien Kidney Center

5323 Harry Hines Blvd.

Dallas, TX 75390 - 8856



Name Role Phone Email Location
Thomas Carroll, Ph.D
Animal Model Core Co-Director

Orson W. Moe, M.D.
O'Brien Core Center Director

Genelyn Vadney
Research Technician

Request/Order Animal Models

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Cre activatable cDNAs (6)
Cre inducible reporters (9)
Cre lines (16)
Dox inducible lines (4)
Doxycycline inducible reporters (1)
Reporter Lines Constitutive reporters (6)
rtTA/tTA inducible cDNAS (3)
Loss of Function Alleles: Germline Nulls (10)
Reagents (1)
Transgenic Core - HNF1NB KO (1)
Conditional Alleles (14)