The study of genetically modified mice has greatly expanded our understanding of kidney development and pathophysiology. The U.T. Southwestern O’Brien Kidney Center Animal Model Core provides cutting-edge technology to investigators wishing to generate mouse models for the study of kidney development and/or function.
The Animal Model Core serves three major purposes:
The Core generates and distributes several kidney-specific Cre recombinase and tetracycline-inducible activator and repressor lines to be crossed to floxed or tet responder lines provided by co-investigators. Core personnel assist in generating additional transgenic mice, knockout/in mice, and cell lines, as required by co-investigators. Core personnel also use and train investigators to use various models of organ injury/repair and ex vivo culture. As mentioned, the ultimate purpose of this core is to facilitate research on kidney development and pathophysiology.
All publication require the acknowledgment of the support provided from U.T. Southwestern Medical Center of Dallas, George M. O'Brien Kidney Research Core Center (P30DK079328)
U.T. Southwestern Medical Center of Dallas
O'Brien Kidney Center
5323 Harry Hines Blvd.
Dallas, TX 75390 - 8856
Name | Role | Phone | Location | |
---|---|---|---|---|
Thomas Carroll, Ph.D |
Animal Model Core Co-Director
|
214-648-8147
|
thomas.carroll@utsouthwestern.edu
|
|
Orson W. Moe, M.D. |
O'Brien Core Center Director
|
orson.moe@utsouthwestern.edu
|
||
Genelyn Vadney |
Research Technician
|
genelyn.vadney@utsouthwestern.edu
|
NA8.214
|
Request/Order Animal Models |
► Cre activatable cDNAs (7) | |||
Name | Description | Price | |
---|---|---|---|
Cagg-LSL-Wnt9b-IRES-GFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Catnb exon3 flox |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Rosa LSL Yap5SA |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Rosa-LSL-DTA |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Rosa-LSL-DTR |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Rosa-lsl-rtTA |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Rosa-LSL-Wnt1GFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
► Cre inducible reporters (9) | |||
Name | Description | Price | |
EF1a-LSL-Crb3GFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Rosa-Confetti |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Rosa-LSL- Lacz |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Rosa-LSL- myrTom/myrGFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Rosa-LSL- Tomato |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Rosa-LSL- YFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Rosa-LSL-Golgi-cherry |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Rosa-LSL-myrTom |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Rosa26-tetO-Cre |
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
||
► Cre lines (16) | |||
Name | Description | Price | |
CaggCreERT2 |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Foxd1Cre-eGFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Foxd1CreERT2 |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Gli1CreERT2 |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Hoxb7Cre |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
KspCadherin Cre |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
KspCreERT2 |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Osr1CreERT2 |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Pkhd1Cre |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Rarb2Cre |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Six2Cre-eGFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Six2CreERT2 |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Slc34a1CreERT2 |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Smoc2CreERT2 |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Sox2Cre |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
T-CreERT2 |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
► Dox inducible lines (4) | |||
Name | Description | Price | |
KspCad-rtTA |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
KspCad-tTA |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Pdgfrb-rtTA |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Podocin-rtTA |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
► Doxycycline inducible reporters (1) | |||
Name | Description | Price | |
Tre-H2bGFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
► Reporter Lines Constitutive reporters (6) | |||
Name | Description | Price | |
Axin2-GFP |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Gucy1a3-GFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Mef2c-GFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Meis1-GFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Pax8-YFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Smoc2-tdTomato |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
► rtTA/tTA inducible cDNAS (3) | |||
Name | Description | Price | |
Tre-H2B-GFP |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Tre-Lin28a |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
Tre-MycN |
|
Internal
$100.00
each
External $150.00 each Commercial/Industry $400.00 each |
|
► Loss of Function Alleles: Germline Nulls (10) | |||
Name | Description | Price | |
Btbd11-/- |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Fam132a -/- |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Fam19a5 -/- |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Fat4+/- |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Smoc2-/- |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Wnt4+/- |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Wnt7b exon 3 deletion |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Wnt7b exon 3-4 deletion |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Wnt9b neo/+ |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Wnt9b+/- |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
► Reagents (1) | |||
Name | Description | Price | |
Reagents |
|
Inquire | |
► Transgenic Core - HNF1NB KO (1) | |||
Name | Description | Price | |
Transgenic Core - HNF1NB KO |
Internal
$2,700.00
each
External $2,700.00 each |
||
► MTA ONLY (1) | |||
Name | Description | Price | |
MTA (Material Transfer Agreement) ONLY |
- Requester is only submitting a request for a Material Transfer Agreement. - DO NOT initiate this request if you are also requesting a mouse line from the O'Brien Kidney Center |
Inquire | |
► Conditional Alleles (14) | |||
Name | Description | Price | |
Catnb flox/flox |
|
Internal
$150.00
each
External $200.00 each |
|
cMyc flox/flox |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
cMyc/Nmyc flox/flox |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Lats 1 c/c |
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
||
Lats 2 c/c |
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
||
Lats1/2 flox/flox |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Lkb1 flox/flox |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Mycn flox/flox |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Pkd1 flox/flox |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Srf flox/flox |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Taz flox/flox;Yap flox/flox |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Wnt7b exon 1 flox |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Wnt7b exon3 flox |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |
|
Wnt9b exon 2 flox |
|
Internal
$150.00
each
External $200.00 each Commercial/Industry $400.00 each |