UTSW Structural Biology Laboratory

<p>AIM&nbsp;provides assistance to researchers with collection and assessment of Patient Reported Outcomes, behavioral data, and measures of fitness and body composition.</p>

The Biospecimen Extraction Resource provides a centralized laboratory for standardized, high quality DNA, RNA and protein extraction from blood, tissues, saliva, cells, or other patient derived biospecimens.

The Bone Histomorphometry Core Laboratory provides histomorphometric analyses of nondecalcified bone specimens, including processing mouse bone specimens for nondecalcified histology and performing static and dynamic histomorphometric analyses of mouse bone specimens.

The Characterized Cell Line distributes well characterized and validated cell lines to researchers across the world and offers cell line validation using short tandem repeats STR profiling.

The purpose of the Core for Biomolecular Structure and Function (CBSF) is to provide recombinant &nbsp;protein production, protein characterization, binding studies and structural biology (X-ray crystallography)&nbsp;services to MD Anderson Cancer Center and the wider Texas Medical Center.

The DNA Methylation Core is funded by the Center for Cancer Epigenetics and provides services related to the analysis of DNA methylation for researchers at the University of Texas M.D. Anderson Cancer Center.

The Gene Editing Cellular Model Core Facility provides custom cellular model construction services using two technical platforms.

The Genetically Engineered Mouse Facility provides unique models with wide application to basic and translational research. The GEMF supplies indispensable expertise to generate these models in an efficient and cost effective manner using state of the art procedures.

The mission of the High Resolution Microscopy Facility is to provide scanning and transmission electron microscopy services to researchers.

The Laboratory Animal Genetic Service Core provides services for speed congenics, background characterization, microbial PCR testing, rodent STR and murine genetic consultations.

The primary goal of this facility is to offer conventional and molecular cytogenetic services, including species identification, karyotyping, analysis of genomic instability, fluorescence in situ hybridization and spectral karyotyping

The Monoclonal Antibody Facility develops high quality, cost effective customized MAbs to meet the basic, translational, and clinical research needs of MD Anderson investigators.

The Flow Cytometry and Cellular Imaging Facility was established to provide access to state of the art cell analysis technology for researchers, and provides cell sorting, analytical flow cytometry, cellular imaging and custom monoclonal antibody mAb conjugations to its users.

The NMR facility is used for structure determination of compounds developed in drug discovery, pharmacology, and diagnostic imaging laboratories.

The mission of the Pharmaceutical Chemistry Facility is to assist researchers with the design and synthesis of compounds for use in cancer research.

The Protein Array and Analysis Core PAAC at the University of Texas MD Anderson Cancer Center Science Park provides investigators access to innovative and cutting edge cancer research tools for the discovery and characterization of novel proteinprotein interactions.

The mission of the Proteomics and Metabolomics Core Facility is to provide the research community with cutting edge expertise and services for sensitive, precise, and accurate measurement of proteins and metabolites using mass spectrometrybased technologies.p</p>

Functional Proteomics Reverse Phase Protein Array RPPA Core provides cancer center members with access to a powerful, highthroughput, quantitative costeffective antibodybased assay to characterize basal or ligandinduced protein expression and modification, and timeresolved responses appropriat

The Research Histology Core Laboratory includes specialized equipment for immunohistochemistry, fluorescent in situ hybridization FISH, laser capture microdissection, and tissue microarray construction.

The Flow Cytometry and Cell Imaging Core Facility at Science Park provides cutting edge cell analysis resources. These include cell sorting and analytical flow cytometry to phenotype, quantify and isolate cells and confocal microscopy to capture high resolution images.p

The Molecular Biology Core Facility at Science Park provides investigators access to sophisticated and stateoftheart molecular techniques, services and instrumentation.

The Science Park NGS facility is built around a user group of 30 cancer researchers at MD Anderson Science Park, UT Austin, and Texas State University San Marcos.

The Science Park Research Histology, Pathology Imaging Core provides investigators with expert imaging and experimental pathology support. Our staff consult with investigators to formulate an integrated imaging, pathology and histology protocol for each study.

The Sequencing and Microarray Facility provides essential genomic analysis services to support researchers in basic science, translational, and populationbased research programs

The Sequencing and Noncoding RNA Program is one of an MDA institution supported shared genomic service resources providing not only instrumentation but also expertise in applications of next generation sequencing and microarray services to investigators

<p>The Small Animal Imaging Facility provides access to imaging instrumentation and expertise that allows researchers to integrate powerful and cuttingedge imaging technologies into routine preclinical research with confidence that their scientific objectives will be achieved.</p>

The shRNA and ORFeome core Facility makes the following libraries available to MD Anderson members human and murine shRNA libraries, human ORFeome collaboration and LentiORF libraries. The core not only provides center members with individual shRNA and ORF clones but also builds customized librar...

The siRNA Core Facility at MD Anderson performs High Throughput and High Content siRNA screens to assist experimental cancer therapy studies. The cores ultimate goal is to develop relevant three dimensional models that represent the human body..

KAMC focuses on the synthesis and characterization of nanomaterials for imaging, labels for bioassays, and active targeting for in vivo or in vitro diagnostics. The Core studies the interaction of nanoparticles with living cells for application in the targeted delivery of drugs, genes, and proteins.

The RCMI Proteomics and Protein Biomarkers Core Facility is focused on capillary liquid chromatographymass spectrometry LCMS and tandem mass spectrometry LCMSMS to identify, characterize, and quantify proteins. The Proteomics Core develops novel methods, while the Protein Biomarkers Core applies ...

The RCMI Biophotonics Core Facility provides cutting edge technology for the study and manipulation of biological samples using light, including longterm indepth imaging of live tissues and the technology to probe at the molecular level for proteinprotein interactions within live samples.

The BioScope™ II microscope has been engineered to facilitate advanced life science research such as imaging, probing and manipulating biological systems at the nanometric scale. We can determine the micromechanical properties of both biological and non-biological samples.

We offer services to researchers, including access to clinical data and enhanced subject recruiting, and are involved in multiple local and national collaborations with other groups.

The CCTS Biobank consists of a collection of human samples and related clinical and genomic data that are available for collaborative sharing with qualified researchers and owned by contributing investigators conducting research within the Texas Medical Center.

<p>The CTC is an FDA registered facility where tissues are processed to produce cells for clinical applications. It is focused on translating, validating and supporting IND applications at a preclinical level into clinical grade processes.</p>

<p>The Center for Advanced Microscopy provides assisted or unassisted state of the art imaging capabilities including three confocal microscopes, fluorescence lifetime imaging, live animal imaging with an IVIS Lumina, flow cytometry, and a liquid handling multiwell plate reader.</p>

<p>The Flow Cytometry Service Center provides a broad range of assisted and unassisted flow cytometry services from basic 2 color analysis to advanced 14 parameter analysis and multi population cell sorting.</p>

The MR group provides advanced MRI techniques, including selective tissue imaging, magnetic resonance spectroscopic imaging, diffusion tensor imaging to neurological disorders, central nervous system trauma, and drug addiction both in humans and animal models.

The Nanochemistry Service Center provides provides custom synthesis, labeling, and chemical coupling of DNA thioaptamers and nanoparticles and large-scale, high-resolution 3D printing services.

The CTPC services provided are designed to identify and quantitate proteins and their modifications in a broad range of research specimens from simple purified protein samples to biomarker discovery and verification in complex mixtures such as cell and tissue extracts, plasma andor other biofluids

The Quantitative Genomics Microarray Core Lab can perform all techniques associated with a qPCR instrument, quantitative Meso Scale ELISAs and microarrays utilizing Illumina and Agilent arrays.

The Therapeutic Antibody Core aims to provide statewide support and service to advance lead antibodies from academic laboratories to the stage of preclinical development.

The Research Histopathology Core is equipped with the latest available instrumentation. RHC’s instrumentation is operated by highly skilled personnel available to assist in tissue preparation, immunohistochemistry, immunofluorescence, Insitu hybridization, including assay optimization, image anal...