UTSW Structural Biology Laboratory

Overview of Services

The Structural Biology Laboratory (SBL) provides access and assistance with the techniques of X-ray crystallography and single particle cryo-electron microscopy reconstruction, and assistance with structure determination, refinement and interpretation. For X-ray this includes assistance with crystal screening and optimization, in-house X-ray diffraction screening and data collection, synchrotron data collection at the Advanced Photon Source (APS) for single crystals and Small Angle X-ray Scattering (SAXS) measurements. For single particle cryo-EM, this includes assistance with protein sample preparation, grid preparation for negative staining and cryo-EM, grid optimization, collection, processing and analysis of data from in-house microscopes, structure determination and validation.

Core Staff

Diana Tomchick, Ph.D.

Director

214-645-6383

Diana.Tomchick@UTSouthwestern.edu

Zhe (James) Chen, Ph.D.

214-648-1207

Zhe.Chen@UTSouthwestern.edu

Yang Li, Ph.D.

214-645-5849

Yang2.Li@UTSouthwestern.edu

Helen Aronovich

Research Technician

214-645-6382

Helen.Aronovich@UTSouthwestern.edu

Location and hours of operation

Links and Resources

http://www3.utsouthwestern.edu/sbl/