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UTSW Structural Biology Laboratory

Overview of Services

The Structural Biology Laboratory (SBL) provides access and assistance with the techniques of X-ray crystallography and single particle cryo-electron microscopy reconstruction, and assistance with structure determination, refinement and interpretation. For X-ray this includes assistance with crystal screening and optimization, in-house X-ray diffraction screening and data collection, synchrotron data collection at the Advanced Photon Source (APS) for single crystals and Small Angle X-ray Scattering (SAXS) measurements. For single particle cryo-EM, this includes assistance with protein sample preparation, grid preparation for negative staining and cryo-EM, grid optimization, collection, processing and analysis of data from in-house microscopes, structure determination and validation.

Core Staff

Diana Tomchick, Ph.D.




Zhe (James) Chen, Ph.D.



Yang Li, Ph.D.



Helen Aronovich

Research Technician




Location and hours of operation

Hours Location

Monday - Friday

9 AM - 5 PM

24/7 Availability for trained instrument usage    

ND Building, floors 8 & 10

6001 Forest Park Rd.

Dallas, TX 75390-8816

Links and Resources


Name Role Phone Email Location
Diana Tomchick, Ph.D.

Service List

Search available services: View: by category alphabetically
Consumables, EM (9)
Consumables, X-ray (12)
Data collection & structure determination, EM (16)
Data collection and structure determination, X-ray (10)
Instrument Use, X-ray (2)