UTSW Structural Biology Laboratory

Overview of Services

The Structural Biology Laboratory (SBL) provides access and assistance with the techniques of X-ray crystallography, small angle X-ray scattering and high resolution imaging as well as single particle reconstruction in cryo-electron microscopy. For X-ray this includes assistance with crystal screening and optimization, in-house X-ray diffraction screening and data collection, synchrotron data collection at the Advanced Photon Source (APS) for single crystals and small angle X-ray scattering (SAXS) measurements. For single particle cryo-EM, this includes assistance with protein sample preparation, grid preparation for negative staining and cryo-EM, grid optimization, collection, processing and analysis of data from in-house or remote microscopes, structure determination and validation. SBL is on-track to offer Micro-crystal Electron Diffraction (microED) service in 2022.

Core Staff

Diana Tomchick, Ph.D.

Director

214-645-6383

Diana.Tomchick@UTSouthwestern.edu

 

Zhe (James) Chen, Ph.D.

co-Director on Cryo-EM

214-648-1207

Zhe.Chen@UTSouthwestern.edu

 

Yang Li, Ph.D.

Assitant Professor

214-645-5849

Yang2.Li@UTSouthwestern.edu

 

Helen Aronovich

Senior Research Associate

214-645-6382

Helen.Aronovich@UTSouthwestern.edu

 

 

Location and hours of operation

Hours Location

Monday - Friday

9 AM - 5 PM

24/7 Availability for trained instrument usage    

ND Building, floors 8 & 10

6001 Forest Park Rd.

Dallas, TX 75390-8816

Links and Resources

Structural Biology Lab (utsouthwestern.edu)

Contacts

Name Role Phone Email Location
Diana Tomchick, Ph.D.
Director
 
214-645-6383
 
Diana.Tomchick@UTSouthwestern.edu
 
ND10.214A
 
Zhe (James) Chen, Ph.D.
co-Director
 
214-648-1207
 
Zhe.Chen@UTSouthwestern.edu
 
ND10.214F
 

Service List


Search available services: View: by category alphabetically
Consumables, EM (9)
Consumables, X-ray (12)
Data collection & structure determination, EM (15)
Data collection and structure determination, X-ray (10)
Instrument Use, X-ray (2)